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Limited experience with sarcomas, rare cancers, lead to frequent errors in classification and inappropriate therapy.

We hope to lay down very specific methods of diagnosis for pathologists to be better able to review these methods and utilize them effectively.

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Differential Diagnosis of Spindle Cell Sarcomas including Leiomyosarcoma


Brian Rubin, MD, PhD

Professor and Vice-Chair of Pathology; Director, Soft Tissue Pathology; Director, Bone and Soft Tissue Pathology Fellowship Program
Cleveland Clinic
Cleveland, Ohio

Jason L Hornick, MD, PhD

Professor of Pathology
Harvard Medical School
Director of Surgical Pathology; Director, Immunohistochemistry Laboratory
Brigham and Women's Hospital
Boston, Massachusetts

Target Audience

Practicing Surgical Pathologists

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Recognize a sarcoma on a hematoxylin and eosin stained section.
  • Appropriately apply standard immunohistochemical studies to classify/diagnose sarcomas.
  • Select the pertinent/correct molecular diagnostic assays to classify/diagnose sarcomas.
  • Describe and compare differences in therapy amongst different sarcomas.

Accreditation and Credit Designation

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of University Health Services Professional Education Programs (UHS‐PEP) of Virginia Commonwealth University Health System and SARC (Sarcoma Alliance for Research through Collaboration). UHS‐PEP is accredited by the ACCME to provide continuing medical education for physicians.

UHS‐PEP designates this on demand activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosure Statement (Faculty & Planners)

Dr. Hornick and the planners for this educational activity have no relevant financial relationships with commercial interest to disclose.

Dr. Rubin has the following relevant relationships to disclose: Advisory board, Eli Lilly.

In compliance with the ACCME Standards, all relationships reported above have been resolved according to VCU’s Policy on Conflict of Interest. All presenting faculty affirm that they will employ the best available evidence from all sources to support any clinical recommendations made in their presentations. If learners detect any commercial bias in any presentation, they should document their observations on the Activity Evaluation Form.

Copyright Statement

Copyright© SARC (Sarcoma Alliance for Research through Collaboration) – All rights reserved. These materials may be used for personal use only. Any rebroadcast, distribution, or reuse of this presentation or any part of it in any form for other than personal use without the express written permission of SARC is prohibited.

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This program is supported by an independent medical education grant from Janssen


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