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October 16, 2018
Hyatt Regency Chicago
Michigan I, Concourse Level
East Tower
151 E Upper Wacker Drive
Chicago, Illinois

Program Agenda

4:30 PM - 4:35 PM On-site Check-in
4:35 PM - 4:40 PM Welcome and Introduction
Renée Shellhaas, MD, MS (Program Chair)
4:40 PM - 5:00 PM Beyond Seizure Frequency
-What Is a Clinically Meaningful Change?
Dennis J. Dlugos, MD, MSCE
5:00 PM - 5:20 PM "But They Are So Much Better!"
-Beyond Percent Reduction in Seizures
Joseph E. Sullivan, MD
5:20 PM - 5:30 PM Q&A


Renée A. Shellhaas, MD, MS (Program Chair)
Clinical Associate Professor of Pediatrics
Neurology Division
University of Michigan
C.S. Mott Children's Hospital
Ann Arbor, Michigan

Dennis J. Dlugos, MD, MSCE
Professor of Neurology and Pediatrics
Perelman School of Medicine
University of Pennsylvania
Director, Pediatric Epilepsy Program
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania

Joseph E. Sullivan, MD
Associate Professor of Neurology & Pediatrics
University of California, San Francisco (UCSF)
Director, UCSF Pediatric Epilepsy Center of Excellence
San Francisco, California

Continuing Medical Education Information

Target Audience

This activity is intended for physicians engaged in the care of patients with pediatric epilepsy.

Program Overview

Change in seizure frequency is a well-established endpoint for epilepsy treatment efficacy studies and serves as the primary data for regulatory approval of new therapies. Yet, from the perspective of both patients and caregivers, improvements in non-seizure outcomes are also extremely important. There are few validated methods of assessment for non-seizure outcomes for therapeutic trials, however, and the relationships between non-seizure outcomes and seizure burden are incompletely understood. In this activity, expert faculty will discuss implications of considering non-seizure outcomes on trial design and patient selection, as well as how measures such as the clinical global impression of change (CGIC) may be used to define clinically-meaningful response for pediatric epilepsy treatment trials.

Educational Objectives

After completing this activity, the participant should be better able to:

Jointly provided by Postgraduate Institute for Medicine and Miller Medical Communications, LLC.

This live activity is supported by an independent educational grant from Zogenix, Inc.

Physician Continuing Medical Education
The Postgraduate Institute for Medicine designates this live activity for a maximum of 1.50 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Joint Accreditation Statement

In support of improving patient care, this activity has been planned and implemented by the Postgraduate Institute for Medicine and Miller Medical Communications, LLC. Postgraduate Institute for Medicine is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Disclosure of Conflicts of Interest
Postgraduate Institute for Medicine (PIM) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest (COI) they may have as related to the content of this activity. All identified COI are thoroughly vetted and resolved according to PIM policy. PIM is committed to providing its learners with high quality activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of a commercial interest.

Register for What Constitutes a Clinically Meaningful Outcome in Pediatric Epilepsy

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